MC Choi group

Publication

 

• • Hybrid Microtubule-Solid State Nanopores for Single-Molecule Analysis
    M. O’Donohue, C. Gu, B. Kim, K. Lee, S.Lee, C. Ahn, M. C. Choi, M. Kim
    Electrophoresis, (2026) Article
  • Regulation of Microtubule Radial Structure by Competition between Tau and Paclitaxel: Binding and Synchrotron X-ray Studies
    S. Ryu, H. Cho, J. Lee, J. Lee, B. Kim, S. Y. Lee, S. Min, G. Lee, Y. Li, S. Feinstein, C. Safinya, M. C. Choi
    Biophysical Journal, (2026) Article
  • A model of the microtubule cytoskeleton of the axon-initial-segment in mixtures of tubulin, tau, and GTP
    P. Kohl, C. Song, B. Fletcher, P. Chung, R. L. Best, H. Miler, L. Wilson, M. C. Choi, Y. Li, S. Feinstein, C. Safinya
    Biophysical Journal, (2026) Article
  • Spatiotemporally-controlled droplet merging reveals 2D diffusion dynamics of multi-component surfactants
    H. Jang, D. Jeong, B. Oh, S. Lee, H. Cho, S. Choi, C. Hyeon, C. Ahn, H. Lee, M. C. Choi
    Journal of Colloid and Interface Science, 138176 (2025) Article
  • Fractionation by Spatially Heterogeneous Diffusion: Experiments and the Two-Component Random Walk Model
    H. Kim, K. Lee (Co-first), G. Firisa, J. Lee, M. C. Choi, Y. Kim
    JACS, 146, 37 (2024) Article

News KAIST NEWS “‘불균일 확산’ 160년 난제 풀다​“, October 2 2024

Awards “이근민  2024 KAIST G-Day 특별포상 (연구부문) 수상”;“이근민  2025 KAIST 공과대학 박사학위 우수논문상 수상”;“이근민  2024 한국물리학회 가을총회 우수발표상 수상”;“김용정 최명철교수 2025 KAIST 리서치데이 융합연구상 수상”; “수리과학과 김용정교수 KAIST Q-Day 특별포상 수상”

• • Water Hydrogen-Bond Mediated Layer by Layer Alignment of Lipid Rafts as a Precursor of Intermembrane Processes
    S. Lee, J. H. Bak, Y. Lee, D. Jeong, J. Lee, K. K. Lee, H. Cho, H. H. Lee, C. Hyeon, M. C. Choi
    JACS, 145, 20 (2024) Selected as Supplementary Cover of the Issue Article Cover image

News KAIST NEWS “지질 뗏목의 원리 밝혀 질병 치료에 희소식“, June 4 2024

• • Complexes of tubulin oligomers and tau form a viscoelastic intervening network cross-bridging microtubules into bundles
    P. A. Kohl, C. Song, B J. Fletcher, R. L. Best, C Tchounwou, X. G. Garcia Arceo, P. J. Chung, H. P. Miller, L Wilson, M. C. Choi, Y. Li, S. C. Feinstein, C. R. Safinya
    Nature Communications, 15 2362 (2024) Article

• • Regulation of Interfacial Anchoring Orientation of Anisotropic Nanodumbbells
    H. Jang, C. Song, B. Kim, C. Lee, J. Lee, Y. Han, I. An, J. H. Kim, J. Nam, M. C. Choi
    ACS Macro Letters, 12 1298 (2023) Selcted as Supplementary Cover of the Issue Article Cover image 

• • Synchrotron X-ray Study of Intrinsically Disordered and Polyampholytic Tau 4RS and 4RL under Controlled Ionic Environment
    H. Cho, J. Lee, H. Nho, K. Lee, B. Gim, J. Lee, J. Lee, K. Ewert, Y. Li, S. Feinstein, C. R. Safinya, K. S. Jin, M. C. Choi
    The European Physical Journal E: Festschrift in honor of Fyl Pincus, 46:73 (2023) Article

• • Ionic contrast across a lipid membrane for Debye length extension: towards an ultimate bioelectronic transducer
    D. Lee, W. H. Jung, S. Lee, E. S. Yu, T. Lee, J. H. Kim, H. S. Song, K. H. Lee, S. Lee, S. K. Han, M. C. Choi, D. J. Ahn, Y. S. Ryu, C. Kim
    Nature Communications, 12 3741 (2021) Article

• • 튜불린 기반 단백질 나노튜브 개발 및 항암제 전달체로의 응용
    J. Lee, M. C. Choi
    방사광 과학과 기술 (2021) Article

• • A bioinspired and hierarchically structured shape-memory material
    L. Cera, G. M. Gonzalez, Q. Liu, S. Choi, C. O. Chantre, J. Lee, R. Gabardi, M. C. Choi, K. Shin, K. K. Parker
    Nature Materials, 20 242 (2020) Article

• • Tubulin Double Helix: Lateral and Longitudinal Curvature Changes of Tubulin Protofilament
    J. Lee, C. Song (Co-first), J. Lee, H. P. Miller, H. Cho, B. Gim, Y. Li, S. C. Feinstein, L. Wilson, C. R. Safinya, M. C. Choi
    Small, 16 2001240 (2020) Selected as Back Cover of the Issue Article  Cover image

News KAIST NEWS “단백질로 엮어낸 이중나선 개발”, Oct 30 2020

Awards  “이준철 2020 BK21 플러스 사업 우수인력 교육부장관상 수상”; “이준철 2021 춘계한국재료학회 나노 화학/바이오 재료 부문 우수 발표 논문상 수상”; “이준철  한국방사광이용자협회 대학원생 우수 논문상 수상”; “이준철 2022년도 바이오및뇌공학과 졸업식 우수 논문상 수상”; “최명철교수님 2021 국가 연구개발 우수성과 100선 선정되어 정보통신부장관상 수상”; “최명철교수 2022년 공과대학 기술혁신 우수상 수상”; “이준철 2023 한국바이오칩학회 춘계학술대회 Springer 최우수 구두발표상 수상” 

• • Tubulin‐Based Nanotubes as Delivery Platform for Microtubule‐Targeting Agents
    J. Kim, J. Lee (Co-first), J. Lee, H. Keum, Y. Kim, Y. Kim, B. Yu, S. Y. Lee, J. Tanaka, S. Jon, M. C. Choi
    Advanced Materials, 32 2002902 (2020) Selected as Front Cover of the Issue Article   Cover image   

News KAIST NEWS “항암제 표적 단백질 약물전달체로 쓴다?”

• • Aggregation and Cellular Toxicity of Pathogenic or Non-pathogenic Proteins
    S. Lee, M. C. Choi, K. A. Adem, S. Luckman, T. Kim
    Scientific Reports, 10 5120 (2020) Article

• • Microtubules and Tubulin Oligomers: Shape Transitions and Assembly by Intrinsically Disordered Protein Tau and Cationic Biomolecules
    C. Safinya, P. Chung, C. Song, Y. Li, H. P. Miller, M. C. Choi, U. Raviv, K. Ewert, L. Wilson, S. Feinstein
    Langmuir, 35 15970 (2019) Article

• • Molecular Switches Regulating Assembly Transitions of Biological Molecules: Tubulin, Amylin and Lipids
    D. Jeong, S. Lee, J. Lee, H. Jang, S. Lee, M. C. Choi
    AAPPS Bulletin, (2019)

• • Inhibition of Human Amylin Aggregation and Cellular Toxicity by Lipoic Acid and Ascorbic Acid,  Molecular Pharmaceutics
    S. Azzam, H. Jang, M. C. Choi, H. Alsafar, S. Lukman, S. Lee
    Molecular Pharmaceutics, 4 15 2098 (2018) Article

• • Comparison between 102k and 20k PEO Depletants in Osmotic Pressure Measurements of Interfilament Forces in Cytoskeletal Systems
    P. Chung, C. Song, J. Deek, H. P. Miller, Y. Li, M. C. Choi, L. Wilson, S. Feisntein, C. Safinya
    ACS Macro Letters, 7 2 228 (2018) Article

• • DPPC 다중막의 수직 구조 향상을 유도하는 콜레스테롤에 의한 리플 상에서 정렬된 액체상으로의 상전이: 싱크로트론 X선 반사도 연구
    S. Lee, M. C. Choi
    방사광 과학과 기술, (2017) Article

• • Lattice Boltzmann simulations for water coalescence
    S. J. Lim, M. C. Choi, B. M. Weon, B. Gim
    Applied Physics Letters, 111 101602 (2017) Article

• • Holographic deep learning for rapid optical screening of anthrax spores
    Y. Jo, S. Park, J. Jung, J. Yoon, H. Joo, M. Kim, S. Kang, M. C. Choi, S. Y. Lee, Y. Park
    Science Advances, 3(8) e1700606 (2017)

• • Synchrotron small-angle X-ray scattering and electron microscopy characterization of structures and forces in microtubule/Tau mixtures
    P. Chung, C. Song, H. P. miller, Y. Li, U. Raviv, M. C. Choi, L. Wilson, S. C. Feinstein, C. R. Safinya
    Methods in Cell Biology, 141 155 (2017) Article

• • Vertical order of DPPC multilayer enhanced by cholesterol-induced ripple-to-liquid ordered (LO) phase transition: Synchrotron X-ray reflectivity study
    S. Lee, D. -W. Jeong, M. C. Choi
    Current Applied Physics, 17(3) 392 (2017) Article

• • Paclitaxel suppresses Tau-mediated microtubule bundling in a concentration-dependent manner
    M. C. Choi, P. Chung, C. Song, H. P. Miller, E. Kiris, Y. Li, L. Wilson, S. C. Feinstein, C. R. Safinya
    Biochimica et Biophysica Acta – General Subjects, 1861, 1(A) 3456 (2017) Article

• • Enhanced stability of freestanding lipid bilayer and its stability criteria
    D. -W. Jeong, H. Jang, S. Choi, M. C. Choi
    Scientific Reports, 6 38158 (2016) Article News

News KAIST NEWS “지질 뗏목의 원리 밝혀 질병 치료에 희소식“, June 4 2024

• • Tau mediates microtubule bundle architectures mimicking fascicles of microtubules found in the axon initial segment
    P. Chung, C. Song, J. Deek, H. P. Miller, Y. Li, M. C. Choi, L. Wilson, S. C. Feinstein, C. R. Safinya
    Nature Communications, 7 12278 (2016) Article

• • The effect of multivalent cations and Tau on paclitaxel-stabilized microtubule assembly, disassembly, and structure
    C. R. Safinya, P. J. Chung, C. Song, Y. Li, K. Ewert, M. C. Choi
    Advances in Colloid and Interface Science, 232 9 (2016) Article

• • Direct force measurements reveal protein Tau confers short-range attractions and isoform-dependent steric stabilization to microtubules
    P. J. Chung, M. C. Choi (Co-first), H. P. Miller, H. E. Feinstein, U. Raviv, L. Wilson, S. C. Feinstein, C. R. Safinya
    Proceedings of National Academy of Sciences, 112 E6416 (2015) Article  News

News NEWS “알츠하이머병 막아주는 Tau 단백질의 구조와 기능 규명“, Dec 16 2015; NEWS “2015 KAIST 10대 연구 성과에 선정 수상”, Aug 18 2016; YouTube “[2015 KAIST 연구성과] 알츠하이머병의 원인이 되는 Tau 단백질의 역할을 밝히다-바이오및뇌공학과 최명철교수“, 2015

• • Shape-controlled percolation transition in 2D random packing of asymmetric dimers 
    Y. Han, J. Lee, S. Choi, M. C. Choi, M. W. Kim
    Europhysics Letters, 109 66002 (2015) Article

• • Fluorescence Recovery after Merging a Surfactant-Covered Droplet: A Novel Technique to Measure the Diffusion of Phospholipid Monolayers at Fluid/Fluid Interfaces
    D. Jeong, K. Kim, S. Lee, M. C. Choi, S. Choi
    Langmuir, 10(48) 14369 (2014) Article

• • Surface Charge Regulation of Carboxyl Terminated Polystyrene Latex Particles and Their Interactions at the Oil/Water Interface
    K. Kim, K. Park, G. Kim, H. Kim, M. C. Choi, S. Choi
    Langmuir, 30(41) 12164 (2014) Article

• • Surface charge effects on optical trapping of nanometer-sized lipid vesicles
    S. Park, S. Choi, C. Song, M. W. Kim, M. C. Choi
    Soft Matter, 10 8406 (2014): Cover of the issue Article   Cover image

• • Transformation of taxol-stabilized microtubules into inverted tubulin tubules triggered by a tubulin conformation switch
    M. A. Ojeda-Lopez, D. J. Needleman(Co-first), C. Song(Co-first), A. Ginsburg, Y. Li, H. P. Miller, L. Wilson, U. Raviv, M. C. Choi, C. R. Safinya
    Nature Materials, 13 195 (2014) Article  News  Science Perspective

News KAIST NEWS “단백질 나노튜브의 자기조립 분자스위치 발견“, Jan 1 2021; KAIST NEWS “최명철 교수팀 연구 성과, Science 지 Perspective에 소개“, Mar 11 2014   

• • Spontaneous unilamellar polymer vesicles in aqueous solution
    T. Kim, C. Song, Y. Han, J. Jang, M. C. Choi
    Soft Matter, 10 484 (2014) Article

• • 싱크로트론 소각 X-선 산란을 이용한 단백질 나노튜브의 구조와 상호작용
    J. Lee, J. Lee, C. Song, M. C. Choi
    고분자 과학과 기술, 24(6) 596 (2013) Article

• • Ion specific effects in bundling and depolymerization of taxol-stabilized microtubules
    D. J. Needleman, M. A. Ojeda-Lopez, U. Raviv, H. P. Miller, Y. Li, C. Song, S. C. Feinstein, L. Wilson, M. C. Choi, C. R. Safinya
    Faraday Discussions, 166 31 (2013) Article

• • Shape-induced Chiral Ordering in Two-dimensional Packing of Snowmenlike Dimeric Particles
    Y. Han, J. Lee, S. Choi, M. C. Choi, M. W. Kim
    Physical Review E, 88 032202 (2013) Article

• • High-throughput nanoscale lipid vesicle synthesis in a semicircular contraction-expansion array microchannel
    J. Lee, M. G. Lee, C Jung, Y. Park, C. Song, M. C. Choi, H. G. Park, J. Park
    BioChip Journal, 7(3) 210 (2013) Article

• • Simple Super-Resolution Live-Cell Imaging Based on Diffusion-Assisted Förster Resonance Energy Transfer
    S. Cho, J. Jang, C. Song, H. Lee, P. Ganesan, T. Y. Yoon, M. W. Kim, M. C. Choi, H. Ihee, W. D. Heo, Y. K. Park
    Scientific Reports, 3 1208 (2013) Article

• • Nanoscale Assembly in Biological Systems: From Neuronal Cytoskeletal Proteins to Curvature Stabilizing Lipids
    C. R. Safinya, U. Raviv, D. J. Needleman, A. Zidovska, M. C. Choi, M.A. Ojeda-Lopez, K. Ewert, Y. Li, H. P. Miller, J. Oquispe, B. Carragher, C. S. Potter, M. W. Kim, S. C. Feinstein, L. Wilson
    Advanced Materials, 23 2260 (2011) Article

• • Synchrotron Small Angle X-Ray Scattering Quantitatively Detects Angstrom Level Changes in the Average Radius of Taxol-Stabilized Microtubules Decorated with the Microtubule-Associated-Protein Tau
    M. C. Choi, U. Raviv, Y. Li, H. P.  Miller, D. J. Needleman, M. W. Kim, L. Wilson, S. C. Feinstein, C. R. Safinya
    Journal of Physics: Conference Series, 272 012001 (2011) Article

• • Unconventional Salt Trend from Soft to Stiff in Single Neurofilament Biopolymers
    R. Beck, J. Deek, M. C. Choi, T. Ikawa, O. Watanabe, E. Frey, P. Pincus, C. R. Safinya
    Langmuir, 26 18595 (2010) Article

• • Liquid-crystal periodic zigzags from geometrical and surface-anchoring-induced confinement: Origin and internal structure from mesoscopic scale to molecular level
    D. K. Yoon, J. Yoon, Y. H. Kim, M. C. Choi, J. Kim, O. Sakata, S. Kimura, M. W. Kim, I. Smalyukh, N. A. Clark, M. Ree, H. Jung
    Physical Review E, 82 041705 (2010) Article

• • Human Microtubule-Associated-Protein Tau Regulates the Number of Protofilaments in Microtubules: a Synchrotron X-ray Scattering Study
    M. C. Choi, U. Raviv, H. P. Miller, M. R. Gaylord, E. Kiris, D. Ventimiglia, D. J. Needleman, M. W. Kim, L. Wilson, S. C. Feinstein, and C. R. Safinya
    Biophysical Journal, 97 519 (2009): Cover of July 2 issue Article  Cover image

Awards “Selected for Faculty of 1000 Biology and evaluated by Linda Amos”

• • Confined Self-Assembly of Toric Focal Conic Domains (The Effects of Confined Geometry on the Feature Size of Toric Focal Conic Domains)
    Y. H. Kim, D. K. Yoon, M. C. Choi, H. S. Jeong, M. W. Kim, O. D. Lavrentovich, and H. Jung
    Langmuir, 25 1685 (2009) Article

• • Scatterless Hybrid Metal-Single-Crystal Slit For Small-Angle X-ray Scattering and High Resolution X-ray Diffraction
    Y. Li, R. Beck, M. C. Choi, and M. Divinagracia
    Journal of Applied Crystallography, 41 1134 (2008) Article

• • Internal Structure Visualization and Lithographic Use of Periodic Toroidal Holes in Liquid Crystals
    D. K. Yoon, M. C. Choi (Co-first), Y. H. Kim, M. W. Kim, O. D. Lavrentovich, and H. Jung
    Nature Materials, 6 866 (2007) Article

• • Topographic Control of Lipid-raft Reconstitution in Model Membranes
    T. Y. Yoon, C. Jeong, S. Lee, J H Kim, M. C. Choi, S. J. Kim, M. W. Kim, and S. Lee
    Nature Materials, 5 281 (2006) Article

• • Direct Observation of Biaxial Confinement of a Semiflexible Filament in a Channel
    M. C. Choi, C. D. Santangelo, O. Pelletier, J. H. Kim, S. Y. Kwon, Z. Wen, Y. Li, P. A. Pincus, C. R. Safinya, and M. W. Kim
    Macromolecules, 38 9882 (2005) Article

• • Ordered Patterns of Liquid Crystal Toroidal Defects by Microchannel Confinement
    M. C. Choi, T. Pfohl, Z. Wen, Y. Li, M. W. Kim, J. Israelachvili, and C. R. Safinya
    Proceedings of National Academy of Sciences, 14 17340 (2004): Featured on the Cover of Dec 14 issue Article  News
  • Spontaneous Aggregation of Lipids in Supported Membranes with Geometrical Barriers
    T. Y. Yoon, C. Jeong, J. H. Kim, M. C. Choi, M, W. Kim, and S-.D. Lee
    Applied Surface Science, 238 299 (2004) Article

• • Effects of PS-PVP Diblock Copolymer Topography on the Magnetic Properties of CoCrPt Thin Films
    J. Jeong, M. C. Choi, M. W. Kim, and S. Shin
    Physica Status Solidi B, 241 1609 (2004) Article